When a client with endometriosis asks about side effects from leuprolide (Lupron), what should the nurse include?

Leuprolide (Lupron) is a medication commonly used to treat endometriosis by reducing estrogen levels, which can help control the growth of endometrial tissue. One of the notable side effects of this medication is weight gain. This occurs because the reduction in estrogen can lead to changes in metabolism and body composition, often resulting in fat accumulation.

In contrast, the other options do not typically align with the known side effects of leuprolide. Weight loss is not a common consequence, as the drug can lead to hormonal changes that may promote weight gain rather than loss. Frequent headaches are not widely recognized as a prevalent side effect associated with leuprolide, although some patients might experience them, it's not considered a primary concern. Increased energy levels would not be expected either; in fact, due to hormonal changes, some individuals might feel fatigue instead.

Therefore, when discussing side effects with a client taking leuprolide for endometriosis, it's important to inform them that weight gain is a likely possibility, allowing them to prepare for and manage this potential outcome effectively.